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Белки и пептиды в постгеномную эру. Структурно-функциональные исследования для решения фундаментальных задач и направленного конструирования инновационных лекарственных средств

Интенсивные структурные исследования геномов эукариотических и прокариотических организмов, населяющих нашу планету, обусловили новый этап в развитии биологии и ее прикладных направлений - биотехнологии, биомедицины, фармацевтики и других. В настоящее время кажется, что функциональная геномика (транскриптомика) способна дать ответы на новые вызовы современности: указать, какие механизмы обуславливают развитие заболеваний человека и животных, каталогизировать генетические вариации, наличие которых ассоциировано с рисками развития недугов человека и, наконец, разработать технологии коррекции на генетическом уровне «ошибок» природы, наличие которых обуславливает болезни. Однако при ближайшем рассмотрении становится понятно, что в гораздо большей степени современное человечество возлагает надежды на использование других составляющих живой системы - белков и пептидов. Бурный всплеск технологий манипулирования нуклеиновыми кислотами обусловил интенсивное развитие производства диагностических и терапевтических антител для ранней диагностики и эффективного таргетного лечения. Фундаментальные исследования взаимосвязи структуры и функции белков и пептидов играют ведущую роль в настоящее время и будут играть всё большую роль в будущих периодах, так как именно белково-пептидные вещества выполняют основные биологические функции в каждой живой клетке и в организме в целом. Значительный прогресс в белково-пептидной химии был определен внедрением в исследовательскую практику современного масс-спектрометрического анализа и других физико-химических методов, таких как ЯМР-спектроскопия и рентгеноструктурный анализ. Современная наука, занимающаяся изучением белков и пептидов, представляет собой комплексную дисциплину, использующую все современные методы и технологии: приёмы генной инженерии, методы структурной и квантовой химии, походы высокопроизводительного масс-спектрометрического анализа, позволяющие идентифицировать и количественно определять многие тысячи белков и пептидов, создавая их молекулярный каталог со свойственными энзиматическими модификациями, происходящим с белками и пептидами после их синтеза в клетках. Разработка новых технологий исследования белков и пептидов, изучения их посттрансляционных модификаций, количественного определения этих компонентов в биологических объектах, использования их рационального компьютерного дизайна – вот далеко не полный перечень актуальных направлений развития этой приоритетной области знания, определяющей успех современной фармацевтики и персонифицированной медицины в недалеком будущем. Институт биоорганической химии им. академиков М.М.Шемякина и Ю.А.Овчинникова Российской академии наук (ИБХ РАН) является головным учреждением по изучению белков и пептидов в нашей стране. За время существования ИБХ РАН фундаментальные исследования в области белково-пептидной химии снискали международный авторитет и позволили разработать и внедрить в практику белковые и пептидные препараты как в нашей стране, так и за её пределами. На новом этапе своей деятельности мы предлагаем комплексный проект, который состоит из пяти неразрывно связанных с друг другом блоков и охватывает все основные направления современной науки, занимающейся изучением взаимосвязи структуры и функции белков и пептидов. Одним из важных критериев такого исследования будет являться наличие как современных конкурентоспособных технологий анализа полипептидов (масс-спектрометрия, ЯМР-спектроскопия, высокоэффективная хроматография, гетерологичная экспрессия с использованием новых векторных систем, создание трансгенных нокаутных экспериментальных животных и др.), так фундаментальных исследований в области пептидомики и физиологии рецепторов, способных выявить новые функции этого класса природных соединений и положить начало конструированию инновационных лекарственных средств. Наряду с этим, особое внимание будет уделено вопросам обратной генетики, в частности, идентификации пептидов, кодируемых короткими рамками считывания у растений, а также разработке новых алгоритмов для поиска и идентификации пептидов, кодирующихся участками длинных некодирующих РНК. Эти примеры еще раз показывают, что тесное взаимодействие некогда отдельных дисциплин является не только источником и критерием достоверности результатов фундаментальных научных исследований, но и существенно ускоряет их внедрение в практику.

6 Января 2014 года — 31 Декабря 2018 года

Габибов А.Г. (рук.)

Грант, РНФ

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