Method for identification of condition-associated public antigen receptor sequences
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences. We developed a statistical framework for associating receptors to disease from only a small cohort of patients, with no need for a control cohort. Our method successfully identifies previously validated Cytomegalovirus and type one diabetes responsive TCRb sequences.
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Список научных проектов, где отмечена публикация
- Изучение динамики системы клеточного адаптивного иммунитета при флавивирусной инфекции (6 Января 2015 года 31 Декабря 2019 года). . Грант, РНФ.