Vaccine, 2018, 36(12):1599-1605

Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine

Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.

IBCH: 3104
Ссылка на статью в журнале: https://linkinghub.elsevier.com/retrieve/pii/S0264410X18302019
Кол-во цитирований на 08.2024: 14
Данные статьи проверены модераторами 2018-03-14

Список научных проектов, где отмечена публикация

  1. Изучение динамики системы клеточного адаптивного иммунитета при флавивирусной инфекции (6 Января 2015 года — 31 Декабря 2019 года). Лебедев Ю.Б.. Грант, РНФ.