Quantitative profiling reveals minor changes of T cell receptor repertoire in response to subunit inactivated influenza vaccine
Here we performed deep quantitative T cell receptor repertoire profiling in peripheral blood of a healthy volunteer in response to trivalent subunit influenza vaccine. We did not observe significant rebuilding of peripheral blood T cell receptors composition in response to vaccination. However, we found several clonotypes in memory T cell fraction that were undetectable before the vaccination and had a maximum concentration at day 45 after vaccine administration. These cells were found in lower concentration in the course of repertoire monitoring for two years period. Our observation suggests a potential for recruitment of only a limited number of new T cells after each seasonal influenza vaccination.
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Список научных проектов, где отмечена публикация
- Изучение динамики системы клеточного адаптивного иммунитета при флавивирусной инфекции (6 Января 2015 года 31 Декабря 2019 года). . Грант, РНФ.