PLoS Genet, 2021, 17(1):e1009301

Immune fingerprinting through repertoire similarity.

Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the question of how personal that information is and how it can be used to identify individuals has not been explored. Here, we show that individuals can be uniquely identified from repertoires of just a few thousands lymphocytes. We present "Immprint," a classifier using an information-theoretic measure of repertoire similarity to distinguish pairs of repertoire samples coming from the same versus different individuals. Using published T-cell receptor repertoires and statistical modeling, we tested its ability to identify individuals with great accuracy, including identical twins, by computing false positive and false negative rates

Dupic T, Bensouda Koraichi M, Minervina AA, Pogorelyy MV, Mora T, Walczak AM

IBCH: 9039
Ссылка на статью в журнале: https://doi.org/10.1371/journal.pgen.1009301
Кол-во цитирований на 02.2024: 9
Данные статьи проверены модераторами 2021-01-13

Список научных проектов, где отмечена публикация

  1. 724208. . Внебюджетное финансирование.
  2. Взаимодействие генотипа и репертуара Т-лимфоцитов при формировании противовирусного иммунного ответа (27 Октября 2020 года — 31 Декабря 2022 года). Лебедев Ю.Б.. Грант, РНФ.