Immune fingerprinting through repertoire similarity.
Immune repertoires provide a unique fingerprint reflecting the immune history of individuals, with potential applications in precision medicine. However, the question of how personal that information is and how it can be used to identify individuals has not been explored. Here, we show that individuals can be uniquely identified from repertoires of just a few thousands lymphocytes. We present "Immprint," a classifier using an information-theoretic measure of repertoire similarity to distinguish pairs of repertoire samples coming from the same versus different individuals. Using published T-cell receptor repertoires and statistical modeling, we tested its ability to identify individuals with great accuracy, including identical twins, by computing false positive and false negative rates
Список научных проектов, где отмечена публикация
- 724208. . Сommercial.
- Genotype T cells’ repertoire interaction during development of antiviral immune response (October 27, 2020 December 31, 2022). . Grant, RSF.