Mar Drugs, 2023, 21(10):503

Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics

Marine invertebrates constantly interact with a wide range of microorganisms in their aquatic environment and possess an effective defense system that has enabled their existence for millions of years. Their lack of acquired immunity sets marine invertebrates apart from other marine animals. Invertebrates could rely on their innate immunity, providing the first line of defense, survival, and thriving. The innate immune system of marine invertebrates includes various biologically active compounds, and specifically, antimicrobial peptides. Nowadays, there is a revive of interest in these peptides due to the urgent need to discover novel drugs against antibiotic-resistant bacterial strains, a pressing global concern in modern healthcare. Modern technologies offer extensive possibilities for the development of innovative drugs based on these compounds, which can act against bacteria, fungi, protozoa, and viruses. This review focuses on structural peculiarities, biological functions, gene expression, biosynthesis, mechanisms of antimicrobial action, regulatory activities, and prospects for the therapeutic use of antimicrobial peptides derived from marine invertebrates.

IBCH: 10928
Ссылка на статью в журнале: https://www.mdpi.com/1660-3397/21/10/503
Кол-во цитирований на 06.2024: 4
Данные статьи проверены модераторами 2023-11-11

Список научных проектов, где отмечена публикация

  1. Комплексный подход к анализу природных библиотек защитных пептидов: от фундаментальных исследований механизмов антимикробного действия до разработки прототипов новых лекарственных средств для борьбы с антибиотикорезистентными инфекциями (6 Января 2022 года — 31 Декабря 2024 года). Овчинникова Т.В.. Грант, РНФ.