New Type of Interaction of Snake Three-Finger α-Neurotoxins with Nicotinic Acetylcholine Receptors
In a new work, the researches of the Laboratory of Bioengineering of Neuroreceptors and Neuromodulators, the Laboratory of Structural Biology of Ion Channels, the Group for Analysis of the Structure of Membrane Proteins in Silico, and Laboratory of Biomolecular Modeling of the Institute of Bioorganic Chemistry, Russian Academy of Sciences, together with the researches of the National Research Center «Kurchatov Institute», Institute of Biomedical Chemistry, and Lomonosov Moscow State University using α-bungarotoxin (classical three-finger α-neurotoxin with high affinity to α7-nAChR), we showed applicability of cryo-EM to study interactions of α7-nAChR extracellular ligand-binding domain (α7-ECD) with its ligands, despite the proximity of the size of the complex to the lower limit of the sizes of biomolecules available for study by this method of structural biology. The study is published in the Communications Biology. Learn more
14 декабря 2022 года