Rodent neoplastic process models are extensively used in pre-clinical practice to assess the dynamics of tumor development and test anti-cancer drugs, which ensures flexibility of choosing both basic and advanced personalized tumor development models for researchers. Various modern model tumor imaging methods are considered, including fluorescence and bioluminescence imaging, which enable comprehensive assessment, from qualitative evaluation to in vivo monitoring. We believe that the development of autonomous bioluminescent systems in mammalian cells will provide new possibilities for noninvasive imaging of animal physiological processes, including long-term monitoring of tumor progression.