-Комплексный подход к анализу природных библиотек защитных пептидов: от фундаментальных исследований механизмов антимикробного действия до разработки прототипов новых лекарственных средств для борьбы с антибиотикорезистентными инфекциями

January 6, 2022 — December 31, 2024

Ovchinnikova T.V. (PI)

Science-Educational center

Grant, RSF

List of publications

  1. Guryanova SV, Ovchinnikova TV (2022). Innate Immunity Mechanisms in Marine Multicellular Organisms. Mar Drugs 20 (9),
  2. Krenev IA, Panteleev PV, Umnyakova ES, Gorbunov NP, Kostevich VA, Balandin SV, Ovchinnikova TV, Aleshina GM, Berlov MN (2022). In Vitro Modulation of Complement Activation by Therapeutically Prospective Analogues of the Marine Polychaeta Arenicin Peptides. Mar Drugs 20 (10),
  3. Antoshina DV, Balandin SV, Ovchinnikova TV (2022). Structural Features, Mechanisms of Action, and Prospects for Practical Application of Class II Bacteriocins. Biochemistry (Mosc) 87 (11), pages1387–1403
  4. Panina IS, Balandin SV, Tsarev AV, Chugunov AO, Tagaev AA, Finkina EI, Antoshina DV, Sheremeteva EV, Paramonov AS, Rickmeyer J, Bierbaum G, Efremov RG, Shenkarev ZO, Ovchinnikova TV (2023). Specific Binding of the α-Component of the Lantibiotic Lichenicidin to the Peptidoglycan Precursor Lipid II Predetermines Its Antimicrobial Activity. Int J Mol Sci 24 (2), 1332
  5. Bogdanov IV, Streltsova MA, Kovalenko EI, Sapozhnikov AM, Panteleev PV, Ovchinnikova TV (2023). Epithelial-Immune Cell Crosstalk Determines the Activation of Immune Cells In Vitro by the Human Cathelicidin LL-37 at Low Physiological Concentrations. Biomolecules 13 (9), 1316
  6. Guryanova SV, Balandin SV, Belogurova-Ovchinnikova OY, Ovchinnikova TV (2023). Marine Invertebrate Antimicrobial Peptides and Their Potential as Novel Peptide Antibiotics. Mar Drugs 21 (10), 503
  7. Mironov PA, Paramonov AS, Reznikova OV, Safronova VN, Panteleev PV, Bolosov IA, Ovchinnikova TV, Shenkarev ZO (2024). Dimerization of the β-Hairpin Membrane-Active Cationic Antimicrobial Peptide Capitellacin from Marine Polychaeta: An NMR Structural and Thermodynamic Study. Biomolecules 14 (3), 332
  8. Safronova VN, Panteleev PV, Kruglikov RN, Bolosov IA, Finkina EI, Ovchinnikova TV (2024). Novel BRICHOS-related Defensin-like Antimicrobial Peptide from the Marine Polychaeta Arenicola marina. Russ. J. Bioorganic Chem. 50 (3), 629–643
  9. Antoshina DV, Balandin SV, Tagaev AA, Potemkina AA, Ovchinnikova TV (2024). Biotechnological Production of the Recombinant Two-Component Lantibiotic Lichenicidin in a Bacterial Expression System. Russ. J. Bioorganic Chem. 50 (4), 1150–1161
  10. Antoshina DV, Balandin SV, Finkina EI, Bogdanov IV, Eremchuk SI, Kononova DV, Kovrizhnykh AA, Ovchinnikova TV (2024). Acidocin A and Acidocin 8912 Belong to a Distinct Subfamily of Class II Bacteriocins with a Broad Spectrum of Antimicrobial Activity. Int J Mol Sci 25 (18), 10059
  11. Panteleev PV, Pichkur EB, Kruglikov RN, Paleskava A, Shulenina OV, Bolosov IA, Bogdanov IV, Safronova VN, Balandin SV, Marina VI, Kombarova TI, Korobova OV, Shamova OV, Myasnikov AG, Borzilov AI, Osterman IA, Sergiev PV, Bogdanov AA, Dontsova OA, Konevega AL, Ovchinnikova TV (2024). Rumicidins are a family of mammalian host-defense peptides plugging the 70S ribosome exit tunnel. Nat Commun 15 (1), 8925
  12. Finkina EI, Bogdanov IV, Shevchenko OV, Fateeva SI, Ignatova AA, Balandin SV, Ovchinnikova TV (2024). Immunomodulatory Effects of the Tobacco Defensin NaD1. Antibiotics (Basel) 13 (11), 1101