Gut, 2022, 71(11):2194-2204

A novel unconventional T cell population enriched in Crohn's disease

One of the current hypotheses to explain the proinflammatory immune response in IBD is a dysregulated T cell reaction to yet unknown intestinal antigens. As such, it may be possible to identify disease-associated T cell clonotypes by analysing the peripheral and intestinal T-cell receptor (TCR) repertoire of patients with IBD and controls.

Rosati E, Rios Martini G, Pogorelyy MV, Minervina AA, Degenhardt F, Wendorff M, Sari S, Mayr G, Fazio A, Dowds CM, Hauser C, Tran F, von Schönfels W, Pochhammer J, Salnikova MA, Jaeckel C, Gigla JB, Sabet SS, Hübenthal M, Schiminsky E, Schreiber S, Rosenstiel PC, Scheffold A, Thomas PG, Lieb W, Bokemeyer B, Witte M, Aden K, Hendricks A, Schafmayer C, Egberts JH, Mamedov IZ, Bacher P, Franke A

Department of Genomics of Adaptive Immunity, Laboratory of comparative and functional genomics

: 10.1136/gutjnl-2021-325373
Scopus: 2-s2.0-85137198012
: 35264446
IBCH: 9934
Ссылка на статью в журнале: https://gut.bmj.com/lookup/doi/10.1136/gutjnl-2021-325373
Кол-во цитирований на 09.2024: 25
Данные статьи проверены модераторами 2022-03-18

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