Synthesis (Stuttg), 2021, 53(23):4428-4432

A Facile Synthesis of 2-Aminopropane-1,2,3-tricarboxylic Acid and Its Symmetrical Dimethyl Ester

A new convenient synthetic route to 2 - aminopropane-1,2,3-tricarboxylic acid is described. The first two stages of the three-step synthesis are performed in a one-pot procedure and include the cyclization of hippuric acid with DCC followed by treatment with methyl bromoacetate to yield an alkylated oxazolone. Its hydrolysis with HCl provides 2 - aminopropane-1,2,3-tricarboxylic acid as its HCl salt. Esterification of the resulting acid with methanol in the presence of thionyl chloride leads selectively to its symmetrical diester.

IBCH: 9547
Ссылка на статью в журнале: http://www.thieme-connect.de/DOI/DOI?10.1055/s-0040-1720389
Кол-во цитирований на 07.2024: 1
Данные статьи проверены модераторами 2021-11-11

Список научных проектов, где отмечена публикация

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