Molecular deconvolution of the neutralizing antibodies induced by an inactivated SARS-CoV-2 virus vaccine.
The rapid emergence and persistence of the pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has had enormous impacts on global health and the economy. Effective vaccines against SARS-CoV-2 are urgently needed to control the coronavirus disease 2019 (COVID-19) pandemic, and multiple vaccines have been found to be efficacious in preventing symptomatic COVID-19(Polack et al., 2020; Wu et al., 2020; Jones and Roy, 2021). We have developed a traditional beta-propiolactone-inactivated aluminum hydroxide-adjuvanted whole-virion SARS-CoV-2 vaccine (BBIBP-CorV), which elicited protective immune responses in clinical trials (Wang et al., 2020; Xia et al., 2021). The vaccine has been granted conditional approvals or emergency use authorizations (EUAs) in China and other countries.
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- -Структурные и кинетические особенности презентации антигенов как ключ к пониманию механизмов индукции аутоиммунных патологий и лимфомогенезиса (July 1, 2017 June 30, 2023). . Grant, RSF.