Structural organization of Toll-like receptors and their signaling complexes, according to solution NMR spectroscopy

April 20, 2022 — December 31, 2024

Arseniev A.S. (PI), Mineev K.S. (PI), Goncharuk M.V. (Co-PI), Kot E.F. (Co-PI), Lushpa V.A. (Co-PI), Boldyrev I.A., Kornilov F.D., Motov V.V.

Laboratory of biomolecular NMR-spectroscopy, Laboratory of lipid chemistry

Grant, RSF

List of publications

  1. Kornilov FD, Shabalkina AV, Lin C, Volynsky PE, Kot EF, Kayushin AL, Lushpa VA, Goncharuk MV, Arseniev AS, Goncharuk SA, Wang X, Mineev KS (2023). The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors. Nat Commun 14 (1), 1503
  2. Kislova S, Motov V, Myasnyanko I, Pytskii I, Goncharuk S, Boldyrev I (2024). Conformational transitions of maleic acid segment drive pH induced changes in SMA polymer structure and solubility. J Mol Liq 398,
  3. Lushpa VA, Goncharuk MV, Talyzina IA, Arseniev AS, Bocharov EV, Mineev KS, Goncharuk SA (2024). TIR domains of TLR family-from the cell culture to the protein sample for structural studies. PLoS One 19 (7), e0304997
  4. Motov VV, Kot EF, Kislova SO, Bocharov EV, Arseniev AS, Boldyrev IA, Goncharuk SA, Mineev KS (2024). On the Properties of Styrene–Maleic Acid Copolymer–Lipid Nanoparticles: A Solution NMR Perspective. Polymers (Basel) 16 (21), 3009
  5. Lushpa VA, Lin C, Talyzina IA, Goncharuk MV, Bocharov EV, Arseniev AS, Wang X, Goncharuk SA, Mineev KS (2025). The intracellular domain of TLR2 is capable of high-affinity Zn binding: possible outcomes for the receptor activation. FEBS Lett ,