-Белки и пептиды из ядов змей, влияющие на сердечно-сосудистую систему – фундаментальная основа новых кардиопротекторных и гипотензивных препаратов.

January 6, 2021 — December 31, 2023

Utkin Y.N. (PI)

Laboratory of molecular toxinology

Grant, RSF

List of publications

  1. Averin AS, Nenov MN, Starkov VG, Tsetlin VI, Utkin YN (2022). Effects of Cardiotoxins from Naja oxiana Cobra Venom on Rat Heart Muscle and Aorta: A Comparative Study of Toxin-Induced Contraction Mechanisms. Toxins (Basel) 14 (2), 88
  2. Averin AS, Goltyaev MV, Andreeva TV, Starkov VG, Tsetlin VI, Utkin YN (2022). S- and P-type cobra venom cardiotoxins differ in their action on isolated rat heart. J Venom Anim Toxins Incl Trop Dis 28, e20210110
  3. Shaykhutdinova ER, Kondrakhina AE, Ivanov IA, Kudryavtsev DS, Dyachenko IA, Murashev AN, Tsetlin VI, Utkin YN (2022). Synthetic Analogs of 6-Bromohypaphorine, a Natural Agonist of Nicotinic Acetylcholine Receptors, Reduce Cardiac Reperfusion Injury in a Rat Model of Myocardial Ischemia. Dokl Biochem Biophys 503 (1), 47–51
  4. Averin A, Tyurin F, Samodurova K, Starkov V, Andreeva TV, Utkin YN (2022). THE EFFECTS OF COBRA CARDIOTOXINS ON THE PAPILLARY MUSCLE AND LANGENDORF PERFUSED RAT HEART ARE NOT ASSOCIATED WITH ADRENALINE RELEASE. RJBPC 7 (2), 280–285
  5. Tsetlin V, Haufe Y, Safronova V, Serov D, Shadamarshan P, Son L, Shelukhina I, Kudryavtsev D, Kryukova E, Kasheverov I, Nicke A, Utkin Y (2021). Interaction of α9α10 Nicotinic Receptors With Peptides and Proteins From Animal Venoms. Front Cell Neurosci 15, 765541
  6. Dubovskii PV, Ignatova AA, Alekseeva AS, Starkov VG, Boldyrev IA, Feofanov AV, Utkin YN (2023). Membrane-Disrupting Activity of Cobra Cytotoxins Is Determined by Configuration of the N-Terminal Loop. Toxins (Basel) 15 (1), 6
  7. Osipov AV, Averin AS, Shaykhutdinova ER, Dyachenko IA, Tsetlin VI, Utkin YN (2023). Muscarinic and Nicotinic Acetylcholine Receptors in the Regulation of the Cardiovascular System. Russ. J. Bioorganic Chem. 49 (1), 1–18
  8. Averin AS, Berezhnov AV, Pimenov OY, Galimova MH, Starkov VG, Tsetlin VI, Utkin YN (2023). Effects of Cobra Cardiotoxins on Intracellular Calcium and the Contracture of Rat Cardiomyocytes Depend on Their Structural Types. Int J Mol Sci 24 (11), 9259
  9. Severyukhina MS, Ismailova AM, Shaykhutdinova ER, Dyachenko IA, Egorova NS, Murashev AN, Tsetlin VI, Utkin YN (2023). Synthetic Peptide Fragments of the Wtx Toxin Reduce Blood Pressure in Rats under General Anesthesia. Dokl Biochem Biophys 513 (1), 319–323
  10. Shaykhutdinova ER, Severyukhina MS, Kholoshenko IV, Gondarenko EA, Shelukhina IV, Kryukova EV, Ismailova AM, Sadovnikova ES, Dyachenko IA, Murashev AN, Tsetlin VI, Utkin YN (2023). Anti-smoking drugs cytisine and varenicline reduce cardiac reperfusion injury in rat model of myocardial ischemia. Biochimie 216, 108–119
  11. Kini RM, Utkin YN (2023). Molecular Mechanisms of Animal Toxins, Venoms and Antivenoms. Int J Mol Sci 24 (22), 16389
  12. Averin A, Starkov V, Tsetlin V, Utkin Y (2024). Effects of the Heterodimeric Neurotoxic Phospholipase A2 from the Venom of Vipera nikolskii on the Contractility of Rat Papillary Muscles and Thoracic Aortas. Toxins (Basel) 16 (2),
  13. Osipov AV, Kryukova EV, Ojomoko LO, Shelukhina IV, Ziganshin RH, Starkov VG, Andreeva TV, Tsetlin VI, Utkin YN (2024). A New Protein Glosaxin Composed of Noncatalytic Domains of Class PIII Metalloproteinase from the Pit Viper Gloydius saxatilis Venom Inhibits Nicotinic Acetylcholine Receptor. Russ. J. Bioorganic Chem. 50 (3), 706–714