Лиганды ионных каналов с уникальной селективностью

6 Января 2020 года — 31 Декабря 2022 года

Василевский А.А. (рук.)

Лаборатория молекулярных инструментов для нейробиологии

Грант, РНФ

Список публикаций по проекту

  1. Føns S, Ledsgaard L, Nikolaev MV, Vassilevski AA, Sørensen CV, Chevalier MK, Fiebig M, Laustsen AH (2020). Discovery of a Recombinant Human Monoclonal Immunoglobulin G Antibody Against α-Latrotoxin From the Mediterranean Black Widow Spider (Latrodectus tredecimguttatus). Front Immunol 11, 587825
  2. Tabakmakher VM, Gigolaev AM, Peigneur S, Krylov NA, Tytgat J, Chugunov AO, Vassilevski AA, Efremov RG (2021). Potassium channel blocker crafted by α-hairpinin scaffold engineering. Biophys J 120 (12), 2471–2481
  3. Chernykh MA, Kuldyushev NA, Peigneur S, Berkut AA, Tytgat J, Efremov RG, Vassilevski AA, Chugunov AO (2021). Derivative of Scorpion Neurotoxin BeM9 Is Selective for Insect Voltage-Gated Sodium Channels. Russ. J. Bioorganic Chem. 47 (4), 854–863
  4. Tabakmakher VM, Kuzmenkov AI, Gigolaev AM, Pinheiro-Junior EL, Peigneur S, Efremov RG, Tytgat J, Vassilevski AA (2021). Artificial Peptide Ligand of Potassium Channel KV1.1 with High Selectivity. J Evol Biochem Physiol 57, 386–403
  5. Gigolaev AM, Lushpa VA, Pinheiro-Junior EL, Tabakmakher VM, Peigneur S, Ignatova AA, Feofanov AV, Efremov RG, Mineev KS, Tytgat J, Vassilevski AA (2022). Artificial pore blocker acts specifically on voltage-gated potassium channel isoform KV1.6. J Biol Chem 298 (11), 102467
  6. Kuzmenkov AI, Peigneur S, Nasburg JA, Mineev KS, Nikolaev MV, Pinheiro-Junior EL, Arseniev AS, Wulff H, Tytgat J, Vassilevski AA (2022). Apamin structure and pharmacology revisited. Front Pharmacol 13, 977440
  7. Gigolaev AM, Pinheiro-Junior EL, Peigneur S, Tytgat J, Vassilevski AA (2022). KV1.2-Selective Peptide with High Affinity. J Evol Biochem Physiol 58 (12), 2048–2057
  8. Mineev KS, Chernykh MA, Motov VV, Prudnikova DA, Pavlenko DM, Kuzmenkov AI, Peigneur S, Tytgat J, Vassilevski AA (2023). A scorpion toxin affecting sodium channels shows double cis–trans isomerism. FEBS Lett 597 (18), 2358–2368
  9. Gigolaev AM, Tabakmakher VM, Peigneur S, Tytgat J, Vassilevski AA (2023). Structural Optimization of an α-Hairpinin Blocking Potassium Channels KV1.3. J Evol Biochem Physiol 59 (1), 192–199