Pathology of the gastrointestinal takes the first place between all illnesses of internal organs of piglets. Piglet gastroenteritis is linked to various critical periods of their livelihood during which immunodeficiency disorders, activation of opportunistic microflora, intestinal dysbiosis appear. Uncontrollable use of antibacterial drugs causes the development of antibiotic resistance of bacterial pathogens. The research aims to study the efficiency of herbal sorbent Hypericum Perforatum L. in the context of complex therapy of acute piglets’ gastroenteritis. The therapy efficiency of herbal sorbent Hypericum Perforatum L. was studied in the context of complex therapy of 119 piglets. For the experiment were taken piglets of age 38,2±3,9 days, weight 6,6 ±0, 2 kg. Piglets of group I (n=51) having gastroenteritis were treating with the drug “Baytril” including enrofloxacin hydrochloride 10% as the active substance, dose 0,5 ml/10 kg of animals weight, which corresponds 5 mg/kg enrofloxacin hydrochloride intramuscularly, 1 time a day in 5 days. Piglets of the group II (n=68) having gastroenteritis were treating with the drug “Baytril” including enrofloxacin hydrochloride 10% as the active substance, dose 0,5 ml/10 kg of animals weight, which corresponds 5 mg/kg enrofloxacin hydrochloride intramuscularly, 1 time a day in 5 days with additional prescription of herbal sorbent Hypericum Perforatum L. in dose 2,0 g per os 1 time a day in 7 days. It was founded that combined therapy of piglet’s gastroenteritis using enrofloxacin hydrochloride and herbal sorbent Hypericum Perforatum L. leads to full recovery for 20,6% more frequently than therapy with enrofloxacin hydrochloride only. During the therapy of ill piglets with a combination of enrofloxacin hydrochloride and herbal sorbent Hypericum Perforatum L. the credible reduction of the phenomenon of the neutrophilic leukocytosis, increasing of the relative amount of T-lymphocytes, T-helpers, and B-lymphocytes, normalization of serum concentration of C-reactive protein, common protein and albumin was found. In the blood of ill animals treated with a combination of enrofloxacin hydrochloride and herbal sorbent Hypericum Perforatum L. comparing to piglets treated with enrofloxacin only the number of leukocytes in peripheral blood credibly reduced and the activity of T-and B-lymphocytes increased. These changes reflect credible anti-inflammatory and immunomodulating effects of the herbal sorbent based on Hypericum Perforatum L. in the treatment of piglet gastroenteritis.