Preclinical studies on systemic toxicity and allergenic properties of amide form of HLDF-6 peptide in order to study the safety of its use as a drug with nootropic activity when administered intranasally were conducted. Studies were performed on male and female SD (Sprague Dawley) rats and CD-1 mice. Test results have demonstrated a lack of toxic effects of the study drug at the doses used in this rote of administration.