SARS‐CoV‐2 penetrates the epithelial barrier of the respiratory tract and invading the airways immune cells can either provide the defense or facilitate virus dissemination. In this study, we compared the phagocytic potential of conducting airway immune cells in response to 100‐nanometer fluorescent particles in the presence or absence of peptide – receptor‐binding domain (RBD) of SARS‐CoV‐2. Mice received 100 nm carboxylate‐modified fluorescent particles dissolved in phosphate buffer (PBS) or 0,1 % solution of RBD of SARS‐CoV‐2. Control mice received particles in 0,1% solution of bovine serum albumin (BSA) and 0,1 % solution of RBD of SARS‐CoV‐2 without particles. Particles were applied to mice oropharyngealy in a dose of 10 million particles per mouse. Conducting airway was dissected and subjected to immunohistochemistry as a whole mount. Specimens were analyzed using confocal laser‐scanning microscopy. 24 hours after the particle application slight infiltration of CD11b⁺ phagocytes was detected in conducting airways of mice that received particles both in protein or peptide solution or alone. Infiltrated airways CD11b⁺ phagocytes did not participate in the uptake of particles dissolved in PBS or BSA. These particles were mostly ingested by CD11c⁺CD169⁺ cells in the luminal side of the airway epithelium. RBD of SARS‐CoV‐2 solution alone stimulates CD11b⁺ phagocytes infiltration to the conducting airway. Dissolved in RBD of SARS‐CoV‐2 solution particles were ingested by both CD11c⁺CD169⁺ cells and CD11b⁺ phagocytes. Thus, RBD of SARS‐CoV‐2 stimulates CD11b⁺ phagocytes infiltration and 100 nm particle uptake in conducting airways.