Laboratory of Chemistry of Metabolic Pathways
The Laboratory was established in 2017 on the basis of the Total Synthesis Group which was created in the Laboratory of Molecular technologies at IBCH RAS, headed by Sergey Lukyanov. The mission of the group is to apply organic synthesis to solving actual problems in biochemistry, molecular biology and medicinal chemistry.
This includes:
- structural design and synthesis of model compounds for studying biochemical processes
- total synthesis of natural products
- design, synthesis and testing of drug candidates
- offering our expertise in organic synthesis to biological and biomedical researchers in collaborative projects
- Studies of fungal bioluminescence
Photograph by Professor Cassius Stevani (University of San Paulo, Brazil)
The Guardian about our work
- Studying bioluminescence of marine worms Chaetopterus variopedatus
Photograph courtesy Dimitri Deheyn, Scripps Institution of Oceanography at UC San Diego
- Studying Studying bioluminescence mechanism of Siberian earthworms Fridericia heliota
- Development of novel class of fluorescent dyes based on GFP chromophore
- Development of anti-influenza drug candidates based on structural analogs of Flutimide
- Enantioselective total synthesis of fungal terpenoid panal from bioluminescent fungus Panellus stipticus
- Studying luminescence mechanism of luminous fungi
- Studying biosynthetic origin of marine luciferins: coelenterazine and Cypridina luciferin
- Developing fluorogenic sensors to important protein targets
Scientific projects
Ilia Yampolsky
Russia, Moscow, Ul. Miklukho-Maklaya 16/10 On the map