The name "Group of Chemistry of Natural Products" recalls the former name of the Institute (as well as the division at Chemistry Department at MSU). The key areas of the research are total synthesis, study of natural products biosynthesis, development of original  chemical transformations, and medicinal chemistry. 

Currently, investigation results in the following scientific directions are published:

1) Skeletal editing of polyclic derivatives (ChemRxiv, 10.26434/chemrxiv-2025-pd06r) 

2) C-H activation by means of 1,5-hydride shift and the related processes for preparation of spirocyclic and heterocyclic compounds (Synthesis, 2021, 53, 4689; )

3) Total synthesis and biosynthesis study of the fragmented and rearranged angucycline antibiotics (Nat. Prod. Rep. 2021, 1506; ChemistrySelect 2021, 11775) 

4) Preparation of the annulated and spirocyclic HIV-1 integrase inhibitors (IJMS 2023, 24, 17354; ChemistrySelect 2024, 9, e202305123, Chem. Heterocycl. Comp. 2024, 544)

5) Development of the synthetic approaches towards hasubanan (Eur. J. Org. Chem. 2022, e202200675; J. Org. Chem. 2023, 9737) and Kopsia alkaloids (Synthesis 2024, 56, 346) 

6) Cycloaddition of imidazol-5-one activated donor-acceptor cyclopropanes with aldehydes (Org. Lett. 2020, 22, 2740; Chem. Heterocycl. Compds. 2020, 56, 1092)

1) An approach for atom swap in tetralines towards chromans was developed   (ChemRxiv, 10.26434/chemrxiv-2025-pd06r)

2) An approach towards unsymmetric julolidines via 1,5-hydride-shift-triggered cyclization is developed (Synthesis, 2021, 4689)

3) Biosynthesis of fragmented and rearranged angucyclinones is revised (Nat. Prod. Rep. 2021, 1506). A series of the corresponding derivatives is synthesized (ChemistrySelect 2021, 11775) 

4) Screening of Structure-Activity Relationship for inhibitors of post-integrational gap repar of HIV-1 is carried out (IJMS 2023, 24, 17354; ChemistrySelect 2024, 9, e202305123, Chem. Heterocycl. Comp. 2024, 544)

5) Tandem [3,3]-sigmatropic rearrangement (J. Org. Chem. 2023, 9737) for synthesis of hasubanan alkaloids (Eur. J. Org. Chem. 2022, e202200675) and Diels-Alder/intramolecular Tsuji-Trost reactions towards Kopsia alkaloids (Synthesis 2024, 346) were studied 

6) A new class of donor-acceptor cyclopropanes and original mechanism of their activation are proposed (Org. Lett. 2020, 22, 2740, Chem. Heterocycl. Compds. 2020, 56, 1092)

Scientific projects

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Andrey Mikhaylov

Russia, Moscow, Ul. Miklukho-Maklaya 16/10 — On the map