A previously unknown modulator of purinergic and FGF-signalization, c-Answer, that stimulates regeneration in cold-blooded animals was lost by poorly regenerating warm-blooded animals, including humans
A group of scientists from the Laboratory of Molecular Bases of Embryogenesis, IBCh RAS, together with colleagues from the Laboratory of Mathematical Methods and Models in Bioinformatics, IPPI RAS developed a bioinformatics method that allows one to reveal genes that appear or disappear at a certain stage of evolution. Using this method, a number of genes were found that disappeared in warm-blooded animals, including humans. For further study, one of the found genes was selected that encodes a previously unknown protein. Using the example of this gene, the validity of the hypothesis about the role of disappeared genes in the progressive development of the brain and in the loss of regenerative ability in warm-blooded animals was confirmed. Also this transmembrane protein (c-Answer) is the new FGF and ADP signaling modulator. The results are published in Cell Reports. Learn more
october 23, 2019