Small RNAs of Mycobacterium tuberculosis Regulate Pathogen Virulence and Host Immune Responses
A team of researchers from the Shemyakin–Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, together with colleagues from the Bach Institute of Biochemistry of the Research Center of Biotechnology of the Russian Academy of Sciences and the Central Tuberculosis Research Institute, conducted a comprehensive study of the roles of the small RNAs MTS1338 and MTS0997 in tuberculosis pathogenesis. The findings demonstrated that these molecules contribute to the regulation of M. tuberculosis metabolism and virulence and can also modulate the host immune response. Thus, MTS1338 and MTS0997 may be regarded as factors coordinating mycobacterial interactions with the host organism and as potential targets for developing new approaches to antituberculosis therapy. This work was supported by Russian Science Foundation Grant No. 22-14-00235 and published in Frontiers in Cellular and Infection Microbiology. Learn more
october 27