Age-dependent astrocytic atrophy and mitochondrial malfunction in human neocortex
Scientists from the IBCh RAS in collaboration with colleagues from other institutes have delved into the intricate cellular changes occurring in the brains of aging adults. The results of the study challenges existing paradigms by uncovering distinct responses to aging in astrocytes and neurons. Key findings include a significant decrease in the amount of reduced mitochondrial cytochromes in astrocytes, signaling potential mitochondrial dysfunction linked to aging. Notably, this phenomenon was not observed in neurons, highlighting cell-specific nuances in the aging process. The findings pave the way for a more nuanced understanding of the aging process, considering cell-type-specific responses within the brain active milieu. The results are published in Nature Communications. Learn more
december 25, 2023