Aging Modulates the Ability of Quiescent Stem Cells in the Hippocampal Dentate Gyrus to be Recruited into Division by Pro‑neurogenic Stimuli
Transient or persistent perturbations of the balance between quiescence and division of the hippocampal stem cells due to a brain pathology or therapy can lead to unfavorable long-term outcomes such as premature depletion of their pool, decreased neuronal renewal, and cognitive deficit. Here, using a recently developed method for detection of de novo dividing cells, the members of the redox biology group and the laboratory of molecular technologies from the Department of Metabolism and Redox Biology, IBCH RAS, in the collaboration with colleagues from IHNA&NPh revealed that long-term stimulation of divisions of quiescent stem cells led to premature exhaustion of their pool and that aging of the brain modulates the ability of the quiescent stem cells to be recruited into the cell cycle by pro-neurogenic stimuli. Results of the study have a number of implications for the practical assessment of drugs and treatments with respect to their action on quiescent stem cells at different stages of life in animal preclinical studies. The work is published in the Molecular Neurobiology.
november 30, 2023