Advancements in cytological profiling techniques have found diverse application in deciphering the mechanisms of antibiotic action and resistance
Researchers from the Laboratory of Antibiotic Resistance and the Laboratory of Molecular Design and Synthesis at the Institute of Bioorganic Chemistry RAS, have compiled a comprehensive overview of the latest strides in phenotypic bacterial screening. The progress in novel physicochemical approaches for such screening, along with enhancements in data processing methodologies, is perspective for comprehensive frameworks to characterize microbial morphology. Notable areas of vigorous advancement encompass novel microbial profiling principles, the integration of machine learning strategies for data interpretation, and the miniaturizing of phenotyping techniques using microfluidic systems. This study was supported by the RSF grant No. 23-24-00409 and has been published in the Antibiotics journal.
august 31, 2023