Plant poly (ADP-ribose) polymerase 1 is a potential mediator of cross-talk between the Cajal body protein coilin and salicylic acid-mediated antiviral defence
The nucleolus and Cajal bodies (CBs) are subnuclear structures with well-known roles in RNA metabolism. The researchers from the Laboratory of functional genomics and proteomics (IBCh, RAS) in collaboration with colleagues from the James Hutton Institute (UK) uncovered a previously unrecognised mechanism by which these structures regulate host defences against virus attack. It was shown that the CB protein coilin interacts with poly(ADP-ribose) polymerase 1, redistributes it to the nucleolus and modifies its function. These events are accompanied by activation of salycilic acid-mediated mechanism leading to the restriction of tobacco rattle virus systemic infection. The results are published in Viruses.
july 13, 2023