Alterations in the CD56 and CD56 T Cell Subsets during COVID-19
Scientists from the IBCh RAS together with the EIMB RAS and Sirius University, carried out a comparative analysis of the fractions of circulating CD56+ NKT-like cells, combining the properties of T- and NK-cells, and CD56– T-lymphocytes in COVID-19 among patients in intensive care units (ICU), patients with moderate severity and convalescents. ICU patients with a fatal outcome had a reduced percentage of NKT-like cells, which indicates the potential role of this cell fraction in the pathogenesis of COVID-19. Scientists propose to consider a decrease in the proportion of NKG2D+ and NKG2A+ cells and an increase in the expression of PD-1 and HLA-DR in both CD56– and CD56+ T cells as markers of COVID-19 progression. The results are published in the International Journal of Molecular Sciences.
june 16, 2023