IBCh authors: Sogomonyan AS, Mirkasymov AB, Zvyagin AV, Shipunova VO
Lectin-Modified Magnetic Nano-PLGA for Photodynamic Therapy In Vivo
Lectin-modified nano-PLGA nanoparticles loaded with photodynamic therapy sensitizer (IR775) and magnetite (mPLGA/IR775) were shown to be effective theranostic agents, realizing effective magnetically assisted targeted delivery, tumor bioimaging, and treatment under external light irradiation. The in vitro and in vivo functionality of these nanoparticles were thoroughly tested, and 100% inhibition of allograft solid tumor growth was shown, thus confirming the great potential of the developed nanoformulation for bioimaging and photodynamic therapy. The results are published in Pharmaceutics. Learn more
february 1, 2023