Chemogenetic emulation of intraneuronal oxidative stress affects synaptic plasticity
Neuronal oxidative stress accompanies numerous brain pathologies, including aging-related dementia and Alzheimer’s disease, the most common neurodegenerative disorder of the elderly population. Although a causative role of neuronal oxidative stress in the development of cognitive aging and neurodegeneration is widely accepted, it has not yet been sufficiently proven, primarily because of the lack of tools for emulating isolated oxidative stress. Here, the members of the redox biology group and the Laboratory of molecular technologies from the Department of Metabolism and Redox Biology, IBCH RAS, in the collaboration with colleagues from Federal Center of Brain Research and Neurotechnologies, Federal Medical Biological Agency, and Pirogov Russian National Research Medical University chemogenetically created isolated oxidative stress in individual neurons and revealed that it reduces long-term potentiation, a form of the cell memory. The observations allow for linking intraneuronal oxidative stress with learning and memory deficit. The work is published in the Redox Biology. Learn more
january 16, 2023