A novel factor of brain plasticity
Scientists from the Laboratory of biomolecular modeling IBCh authors contributed to a study of a single-pass membrane receptor FIBCD1 and its role in neurodevelopmental disorders. This receptor has a high expression level in the brain and its function in the central nervous system was unknown before. It was shown that FIBCD1 as an endocytic receptor for sulfated glycosaminoglycans in the brain extracellular matrix and a novel gene associated with neurodevelopmental disorders, revealing a critical role in nervous system plasticity. Structural aspects of the study includes an original ligand docking framework of the Laboratory, molecular dynamic simulations, homology modeling and AlphaFold structure prediction. The study is published in EMBO Molecular Medicine (IF 14.2)
august 9, 2022