Macrophage Blockade using Nature-Inspired Ferrihydrite for Enhanced Nanoparticle Delivery to Tumor
The rapid elimination of systemically administered drug nanocarriers by the mononuclear phagocyte system (MPS) compromises nanomedicine delivery efficacy. Scientists from the Laboratory of molecular immunology IBCh RAS in collaboration with Russian and Australian colleagues have developed a modern, effective and biocompatible agent for the temporary MPS blockade based on nanosized ferrihydrite particles that mimic endogenous iron associated with ferritin. Preliminary administration of ferrihydrite particles coated with carboxymethyl-dextran increased the blood circulation time of magnetic particles by 9 times and their targeted delivery to the tumor by 24 times, and also showed low toxicity. The work was published in the International Journal of Pharmaceutics.
june 1, 2022