Genetically-encoded BRET-activated photodynamic therapy for the treatment of deep-seated tumors
Team of scientists from the Department of immunology and the Department of Peptide and Protein Technologies IBCh RAS in collaboration with colleagues from Nursery for laboratory animals, GPI RAS and MEPhI introduce the concept of genetically-encoded bioluminescence resonance energy transfer (BRET)-activated photodynamic therapy (PDT). Being targeted to tumor cells, genetically-encoded NanoLuc-miniSOG construct generates internal light source and sensitizer pair, which makes possible PDT effect under BRET activation to treat tumors at virtually unlimited depth. The results are published in the Light: Science & Applications. Learn more
march 16, 2022