Accounting for B-cell behavior and sampling bias predicts anti-PD-L1 response in bladder cancer
Tumor-infiltrating B-cells play important roles in tumor microenvironmet. Scientists from the Genomics of adaptive immunity department IBCh RAS demonstarted that high IgG1/IgA ratio is an important prognostic indicator for several subtypes of bladder cancer, in which it is also associated with the prominence of a cytotoxic gene signature. To achieve better prognostic and predictive value, authors normalized cytotoxic signature against the extent of immune cell infiltration. Developed PRIMUS model which integrated the normalized cytotoxic, as well as B- and NK-cell signatures, allowed highly accurate prediction of response to anti-PD-L1 immunotherapy. The work is published in Cancer Immunology Research.
february 7, 2022