Human Telomerase RNA Protein Encoded by Telomerase RNA is Involved in Metabolic Responses
Telomerase RNA is one of the core components of the telomerase complex and participates in survival mechanisms that are activated under stress conditions. Human telomerase RNA protein (hTERP) is encoded by telomerase RNA and has been recently shown to be involved in autophagy regulation. In this studya team of scientists from the Laboratory of Molecular Oncology of the IBCh RAS, MSU, and SRI PCM FMBA of Russia demonstrated the role of hTERP in the modulation of signaling pathways regulating autophagy, protein biosynthesis, and cell proliferation. The AMPK signaling pathway was affected in cells deficient of hTERP and when hTERP was overexpressed. The appearance of hTERP is important for metabolism switching associated with the accelerated proliferation of cells in healthy and pathological processes. These findings demonstrate the connection between telomerase RNA biogenesis and function and signaling pathways. The results are published in the Frontiers in Cell and Developmental Biology journal.
january 10, 2022