Antigen-specific stimulation and expansion of CAR-T cells using membrane vesicles as target cell surrogates
Development of CAR-T therapy led to immediate success in the treatment of B cell leukemia. Manufacturing of therapy-competent functional CAR-T cells needs robust protocols for ex vivo/in vitro expansion of modified T-cells. In this work, a team of scientists from the IBCh RAS in collaboration with a group of scientists from Dmitry Rogachev National Medical Research Center and colleagues from the Faculty of Biology of Moscow State University have created a new technology for the expansion of CAR T cells using artificial vesicles carrying surface tumor antigens. This approach will allow in the future to obtain CAR T-cells with improved functional properties and to minimize the level of premature "exhaustion" of the CAR T-cell population. This work was supported by Russian Scientific Foundation project No. 17-74-30019 and by the Russian Foundation for Basic Research grant No. 19-29-04087_mk and published in the Small journal. Learn more
november 11, 2021