A versatile platform for bioimaging based on colominic acid-decorated upconversion nanoparticles
An advanced noninvasive method for bioimaging lesion is fluorescence diagnostics using nanoparticles. Lanthanide-doped upconversion nanoparticles (UCNPs) are promising bioimaging agents that emit light under near infra-red excitation, capable of deep penetrating in biotissues with a high signal-to-noise ratio. However, their successful implementation is principally associated with surface functionalization with biopolymers. Scientists from the Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Federal Scientific Research Centre “Crystallography and Photonics”, FSBSI “N.N. Blokhin Russian Cancer Research Center”, Lomonosov Moscow State University of Fine Chemical Technologies and Sechenov First Moscow State Medical University developed a method for the UCNP surface functionalization with endogenous colominic acid conferring “stealth” properties, which led to effective accumulation in the area of inflammation, as well as micro- and macro-blood vessels visualization. The research was published in the journal Biomaterials Science. Learn more
september 3, 2020