Soluble Variant of Human Lynx1 Positively Modulates Synaptic Plasticity and Ameliorates Cognitive Impairment Associated with α7-nAChR Dysfunction
Scientists from the Laboratory of bioengineering of neuromodulators and neuroreceptors, the Laboratory of structural biology of ion channels and the Laboratory of neuroreceptors and neuroregulators Shemyakin-Ovchnnikov Institute together with colleagues from the Faculty of biology of Moscow State University and other russian scientific institutes, found that the intranasal administration of the water-soluble analogue of the human neuromodulator Lynx1, which is a GPI-tethered regulatory protein colocalized with nicotinic acetylcholine receptors (nAChRs) in the brain regions responsible for learning and memory can prevent cognitive impairment associated with dysfunction of the α7 type nicotinic acetylcholine receptor. The work is published in the Journal of Neurochemistry under support of Russian Science Foundation. Learn more
june 1, 2020